AskDefine | Define corticosterone

Dictionary Definition

corticosterone n : secreted by the adrenal cortex; involved in regulating water and electrolyte balance in the body

User Contributed Dictionary



  1. A corticosteroid hormone, produced in the adrenal glands, involved in metabolism.

Extensive Definition

Corticosterone is a 21 carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.


In many species, including rodents, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.
However, in humans, corticosterone is produced primarily in the zona fasciculata of the adrenal cortex. It has only weak glucocorticoid and mineralocorticoid potencies in humans and is important mainly as an intermediate in the steroidogenic pathway from pregnenolone to aldosterone. Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells. Glomerulosa cells are found in the Zona glomerulosa, which is the most superficial region of endocrine cells in the adrenal cortex.

Additional images

Image:Steroidogenesis.gif|Steroidogenesis Image:Deoxycorticosterone.svg|Deoxycorticosterone Image:Aldosterone.svg|Aldosterone
corticosterone in German: Corticosteron
corticosterone in Spanish: Corticosterona
corticosterone in Japanese: コルチコステロン
corticosterone in Occitan (post 1500): Corticosterona
corticosterone in Polish: Kortykosteron
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